collagen adhesion

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) Integrin (3) Phosphatase (2) Platelet-activating Factor Receptor (PAFR) (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Inflammation/Immunology (3)

Targets Recommended: ALCAM/CD166 FAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107588

TC-I 15	Integrin	Cardiovascular Disease
TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC₅₀ values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition .

HY-P1408

Obtustatin	Integrin	Cancer
Obtustatin is a non-RGD disintegrin of 41 residues. Obtustatin can be isolated from Vipera lebetina obtusa venom. Obtustatin is a potent and selective inhibitor of the adhesion of integrin α1β1 to collagen IV. Obtustatin inhibits angiogenesis, and can be used for research of cancer .

HY-N7316

Frangulin B	Others	Inflammation/Immunology
Frangulin B, a natural compound that can be isolated from Rhamnus formosana, is an antagonist of collagen-induced platelet aggregation and adhesion .

HY-158225

Methacrylated Type I collagen Col1MA	Biochemical Assay Reagents	Others
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material. Methacrylated Type I collagen retains the essential properties of natural collagen, including spontaneous fiber self-assembly and enzymatic biodegradability. Methacrylated Type I collagen is capable of self-assembly into fibrous hydrogels, intrinsic support of tissue cells through bioactive adhesion sites, and its biodegradability. After photo-cross-linking CMA, the cell viability of encapsulated mesenchymal stem cells was protected .

HY-N4228

6-Methoxydihydroavicine	Platelet-activating Factor Receptor (PAFR)	Cancer
6-Methoxydihydroavicine is an alkaloid isolated from Zanthoxylum integrifoliolum. 6-Methoxydihydroavicine has antiplatelet activities and inhibits AA-, collagen- and PAF-induced platelet aggregation in vitro .

HY-P1408A

Obtustatin triacetate	Integrin	Cancer
Obtustatin triacetate is a 41-residue non-RGD disintegrin. Obtustatin triacetate can be isolated from the venom of Vipera lebetina obtusa. Obtustatin triacetate is a potent and selective inhibitor of integrin α1β1 adhesion to type IV collagen. Obtustatin triacetate inhibits angiogenesis and may be used in cancer research .

HY-113612

Cytostatin	Phosphatase Apoptosis	Cancer
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin .

HY-113612A

Cytostatin sodium	Apoptosis Phosphatase	Cancer
Cytostatin sodium is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC₅₀ value of 210 nM. Cytostatin sodium exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin sodium can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin sodium belongs to the family of natural product fosriecin .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

Cat. No.	Product Name	Type

HY-158225

Methacrylated Type I collagen Col1MA	3D Bioprintig
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material. Methacrylated Type I collagen retains the essential properties of natural collagen, including spontaneous fiber self-assembly and enzymatic biodegradability. Methacrylated Type I collagen is capable of self-assembly into fibrous hydrogels, intrinsic support of tissue cells through bioactive adhesion sites, and its biodegradability. After photo-cross-linking CMA, the cell viability of encapsulated mesenchymal stem cells was protected .

Methacrylated Type I collagen

Col1MA

3D Bioprintig

Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material. Methacrylated Type I collagen retains the essential properties of natural collagen, including spontaneous fiber self-assembly and enzymatic biodegradability. Methacrylated Type I collagen is capable of self-assembly into fibrous hydrogels, intrinsic support of tissue cells through bioactive adhesion sites, and its biodegradability. After photo-cross-linking CMA, the cell viability of encapsulated mesenchymal stem cells was protected .

Cat. No.	Product Name	Target	Research Area